Laroche M, Ludot I, Thiechart M, Arlet J, Pieraggi M, Chiron P, Moulinier L, Cantagrel A, Puget J, Utheza G
Service de Rhumatologie, CHU Rangueil, Toulouse, France.
Osteoporos Int. 1995;5(4):213-7. doi: 10.1007/BF01774009.
Bearing in mind earlier studies which established a link between arteriosclerosis and mineral loss, or fragility of the bones, and also our recent study showing that patients with arterial disorders of the lower limbs also suffered from osteoporosis, we carried out a histological study of the number and appearance of the intraosseous vessels and trabecular bone volume in the femoral heads of patients undergoing surgery for either fracture of the femoral neck or osteoarthritis of the hip. The number of thick-walled vessels, arterioles or arterial capillaries was significantly diminished in the femoral heads of patients with fractures of the femoral neck (p = 0.007). In addition, in the latter patients, arteriosclerotic vascular lesions (rupture of the internal elastic lamina, medial thickening and fibrosis) were more frequent than in patients with osteoarthritis of hip. The possibility that, through chronic ischemia, arteriosclerosis may lead to disturbance of bone remodelling and loss of the mechanical properties of bone has not been contradicted by these findings.
鉴于早期研究证实了动脉硬化与矿物质流失或骨骼脆弱之间的联系，以及我们最近的研究表明下肢动脉疾病患者也患有骨质疏松症，我们对因股骨颈骨折或髋骨关节炎接受手术的患者股骨头内骨血管数量、外观及小梁骨体积进行了组织学研究。股骨颈骨折患者股骨头内厚壁血管、小动脉或动脉毛细血管数量显著减少（p = 0.007）。此外，与髋骨关节炎患者相比，股骨颈骨折患者的动脉硬化性血管病变（内弹性膜破裂、中层增厚和纤维化）更为常见。这些发现并未反驳动脉硬化可能通过慢性缺血导致骨重塑紊乱和骨力学性能丧失的可能性。
