Ma Heather Ting, Griffth James F, Leung Ping-Chung
Department of Electronic and Information Engineering, Harbin Institute of Technology Shenzhen Graduate School, Room 205C, C Building, HIT Campus, Shenzhen University Town, Xili, Nanshan District, Shenzhen 518055, China.
Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
Biomed Res Int. 2014;2014:620925. doi: 10.1155/2014/620925. Epub 2014 Jun 9.
The pharmacokinetic model has been widely used in tissue perfusion analysis, such as bone marrow perfusion. In the modeling process, the arterial input function is important to guarantee the reliability of the fitting result. However, the arterial input function is variable and hard to control, which makes it difficult to compare results across different studies. The purpose of this study was to establish a muscle-based pharmacokinetic model for bone marrow perfusion without using arterial input function. Erector spinae muscle around the vertebral body was selected as the reference region. The study was carried out in elderly females with different bone mineral densities (normal, osteopenia, and osteoporosis). Quantitative parameters were extracted from the pharmacokinetic model. Parameter K (trans,BM) (contrast agent extravasation rate constants for blood perfusion of the bone marrow) showed a significant reduction in subjects with lower bone mineral density, which is consistent with previous studies. However, muscle perfusion parameters remained unchanged among different groups. The results indicated that the muscle-based model was stable for bone marrow perfusion modeling. Additionally, nonsignificant change in muscle parameters indicated that the diminished perfusion is only a local rather than a systematic change in the bone marrow for osteoporosis.
药代动力学模型已广泛应用于组织灌注分析，如骨髓灌注。在建模过程中，动脉输入函数对于保证拟合结果的可靠性很重要。然而，动脉输入函数是可变的且难以控制，这使得不同研究之间的结果难以比较。本研究的目的是建立一种不使用动脉输入函数的基于肌肉的骨髓灌注药代动力学模型。选择椎体周围的竖脊肌作为参考区域。该研究在具有不同骨密度（正常、骨量减少和骨质疏松）的老年女性中进行。从药代动力学模型中提取定量参数。参数K（trans，BM）（骨髓血液灌注的造影剂外渗速率常数）在骨密度较低的受试者中显著降低，这与先前的研究一致。然而，不同组之间的肌肉灌注参数保持不变。结果表明，基于肌肉的模型对于骨髓灌注建模是稳定的。此外，肌肉参数无显著变化表明，骨质疏松时灌注减少仅是骨髓的局部而非系统性变化。
