Michalek J E, Wolfe W H, Miner J C, Papa T M, Pirkle J L
Armstrong Laboratory, Brooks Air Force Base, Texas 78235, USA.
J Expo Anal Environ Epidemiol. 1995 Apr-Jun;5(2):209-23.
Using responses from a questionnaire detailing herbicide exposure during service in Vietnam and information on job classifications, we investigated the relationship between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) body burden and self-reported exposure in enlisted members of Operation Ranch Hand, the United States Air Force herbicide spraying mission in Vietnam. We constructed three TCDD exposure indices from the questionnaire data: the number of days of skin exposure (DAYS), the percentage of skin area exposed (PCNT), and a combined index (SRI) which was the product of these and the concentration of TCDD in the herbicide. A fourth index (AFI) based on gallons of herbicide sprayed and the number of men on the job was also studied. The regression model most predictive of TCDD levels (R2 = 0.61) included job classification (divided into four categories), the number of days of skin exposure, percent body fat during the tour of duty, and relative change in body fat. A model with job classification alone had an R2 of 0.60. The four exposure indices were constructed to further explain TCDD exposure in the job classifications with the highest potential for exposure: Ranch Hand flight engineers and ground crew. In these two groups, days of skin exposure was the index most significantly associated with TCDD levels. Overall, the best index of exposure was the number of days of skin exposure to herbicide.
利用一份详细记录在越南服役期间除草剂接触情况的调查问卷的回复以及工作分类信息，我们调查了2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）身体负荷与美国空军在越南执行除草剂喷洒任务“牧场工行动”中应征成员自我报告的接触情况之间的关系。我们根据调查问卷数据构建了三个TCDD接触指数：皮肤接触天数（DAYS）、皮肤暴露面积百分比（PCNT）以及一个综合指数（SRI），该综合指数是这两者与除草剂中TCDD浓度的乘积。还研究了基于喷洒除草剂加仑数和作业人数的第四个指数（AFI）。对TCDD水平预测性最强的回归模型（R2 = 0.61）包括工作分类（分为四类）、皮肤接触天数、执勤期间的体脂百分比以及体脂的相对变化。仅包含工作分类的模型R2为0.60。构建这四个接触指数是为了进一步解释在接触可能性最高的工作分类中TCDD的接触情况：“牧场工行动”的飞行工程师和地勤人员。在这两组中，皮肤接触天数是与TCDD水平最显著相关的指数。总体而言，最佳的接触指数是皮肤接触除草剂的天数。
