Muller H K, Lugg D J, Ursin H, Quinn D, Donovan K
Department of Pathology, University of Tasmania, Hobart, Australia.
Pathology. 1995 Apr;27(2):186-90. doi: 10.1080/00313029500169852.
The immune status of 29 members of the Australian National Antarctic Research Expeditions (ANARE) was investigated before, during, and after a 56 day summer voyage to Antarctica and correlated with psychological and physiological parameters. All subjects were healthy. Expedition personnel demonstrated decreased cell mediated immune responses (CMI) assessed by the CMI Multi-test; 21% were hypoergic. The major associated observation was a significant negative correlation with anxiety in Antarctica. However, perceived anxiety was greater before and after the voyage. No significant changes were found in T and B lymphocyte subsets, immunoglobulin and complement components and cutaneous blood flow, nor was there any clinical evidence of illness. Of the hormones examined only cortisol was low predeparture which may reflect increased perceived anxiety at that time. Changes in immune control mechanism were apparent as shown by reduced CMI responses and lowered tetanus antibody levels. Stress factors are postulated to induce depression of the immune response in Antarctica. The association with anxiety suggests that brain peptides or associated cytokines may have a role in mediating these immune events. Such alterations in immune status have implications for health management in isolated and extreme conditions.
对澳大利亚国家南极考察队（ANARE）的29名成员在为期56天的南极夏季航行之前、期间和之后的免疫状态进行了调查，并将其与心理和生理参数相关联。所有受试者均健康。考察队人员通过CMI多项测试评估显示细胞介导免疫反应（CMI）降低；21%的人免疫功能低下。主要相关观察结果是与在南极时的焦虑呈显著负相关。然而，航行前后感知到的焦虑更大。T和B淋巴细胞亚群、免疫球蛋白和补体成分以及皮肤血流量均未发现显著变化，也没有疾病的临床证据。在所检测的激素中，只有出发前皮质醇水平较低，这可能反映出当时感知到的焦虑增加。免疫控制机制的变化很明显，表现为CMI反应降低和破伤风抗体水平下降。推测压力因素会导致在南极的免疫反应受到抑制。与焦虑的关联表明脑肽或相关细胞因子可能在介导这些免疫事件中起作用。这种免疫状态的改变对孤立和极端条件下的健康管理具有重要意义。
