Fu X, Schmitz F J, Govindan M, Abbas S A, Hanson K M, Horton P A, Crews P, Laney M, Schatzman R C
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
J Nat Prod. 1995 Sep;58(9):1384-91. doi: 10.1021/np50123a008.
Extracts and pure compounds isolated from four samples of Dysidea sp. sponges collected from two geographically distinct regions of the Indo-Pacific (Chuuk Atoll and Fiji) were assayed against five different enzyme assays, four of which are relevant to anticancer drug discovery and one of which (15-lipoxygenase) may detect compounds significant in modulating the development of atherosclerotic plaque. The pure compounds that inhibited various enzymes were polybrominated phenols and polybrominated phenoxyphenols. Fourteen of these phenols were isolated, six of which were new compounds. A variety of the phenols inhibited inosine monophosphate dehydrogenase (IMPDH), guanosine monophosphate synthetase, and 15-lipoxygenase. No activity was observed with protein tyrosine kinase pp60v-src or matrix metalloprotease.
从印度洋-太平洋地区两个地理上不同的区域（楚克环礁和斐济）采集的4个海绵样品（Dysidea sp.）中提取的提取物和分离出的纯化合物，针对5种不同的酶测定法进行了检测，其中4种与抗癌药物发现相关，1种（15-脂氧合酶）可检测对调节动脉粥样硬化斑块形成具有重要意义的化合物。抑制各种酶的纯化合物是多溴代酚和多溴代苯氧基酚。分离出了其中14种酚，其中6种是新化合物。多种酚抑制肌苷单磷酸脱氢酶（IMPDH）、鸟苷单磷酸合成酶和15-脂氧合酶。未观察到对蛋白酪氨酸激酶pp60v-src或基质金属蛋白酶的活性。
