van der Kuyl A C, Dekker J T, Goudsmit J
Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam, The Netherlands.
J Virol. 1995 Dec;69(12):7877-87. doi: 10.1128/JVI.69.12.7877-7887.1995.
PCR amplification of baboon endogenous virus (BaEV) long terminal repeat, reverse transcriptase gene, and env fragments from 24 different species of African monkeys indicates that BaEV is less widespread than was formerly thought. Instead of being present in every species of African primates, BaEV can be found only in baboons, geladas, and mangabeys (all belonging to the Papionini tribe) and in African green monkey (Cercopithecus aethiops)subspecies. BaEV, which can be activated from baboon and gelada tissues, was most likely introduced in the germ line only recently (less than a few million years ago) and has not been inherited from a common ancestor of all extant African monkeys. Neighbor-joining and maximum-likelihood analyses of the sequences obtained showed that two distinct virus clusters can be distinguished: the first containing baboon, gelada, and African green monkey BaEV sequences and the second consisting of mandrill and mangabey BaEV sequences. This viral evolutionary tree does not follow host phylogeny, indicating the cross-species transmissions and multiple germ line fixations of the virus must have occurred in the past. BaEV sequences are found in monkeys inhabiting savannas (baboons, geladas, and African green monkeys) as well as forests (managabeys and mandrills) and cluster according to the habitats of their hosts, providing evidence for cross-species transmission in shared habitats.
对来自24种不同非洲猴类的狒狒内源性病毒（BaEV）长末端重复序列、逆转录酶基因和env片段进行聚合酶链反应（PCR）扩增，结果表明BaEV的分布范围比之前认为的要小。BaEV并非存在于每一种非洲灵长类动物中，而仅在狒狒、狮尾狒和白眉猴（均属于狒狒族）以及非洲绿猴（埃塞俄比亚猕猴）亚种中被发现。可从狒狒和狮尾狒组织中激活的BaEV，很可能是最近（不到几百万年前）才引入种系的，并非从所有现存非洲猴类的共同祖先那里遗传而来。对所获得序列进行的邻接法和最大似然法分析表明，可以区分出两个不同的病毒簇：第一个包含狒狒、狮尾狒和非洲绿猴的BaEV序列，第二个由山魈和白眉猴的BaEV序列组成。这一病毒进化树并不遵循宿主系统发育关系，表明该病毒过去必定发生过跨物种传播和多次种系固定。在栖息于稀树草原的猴子（狒狒、狮尾狒和非洲绿猴）以及森林中的猴子（白眉猴和山魈）体内均发现了BaEV序列，并且根据宿主的栖息地聚类，这为共享栖息地中的跨物种传播提供了证据。
