Almendral J, Villacastin J P, Arenal A, Tercedor L, Merino J L, Delcan J L
Departamento de Cardiología, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
Am J Cardiol. 1995 Nov 2;76(13):60D-63D. doi: 10.1016/s0002-9149(99)80494-9.
In the present review 6 lines of evidence will be discussed that suggest a prognostic significance for ventricular arrhythmias in patients with systemic hypertension and left ventricular hypertrophy: (1) in patients with systemic hypertension there is a statistical relation between asymptomatic ventricular arrhythmias and left ventricular hypertrophy; (2) in nonhypertensive left ventricular hypertrophy the prognostic value of ventricular arrhythmias is well known; (3) left ventricular hypertrophy is related to sudden death in patients with systemic hypertension; (4) it is generally acknowledged that ventricular arrhythmias are a frequent cause of sudden death; (5) there is experimental evidence to support the arrhythmic risk of left ventricular hypertrophy; and (6) it has been recently demonstrated that ventricular arrhythmias influence mortality in patients with left ventricular hypertrophy secondary to systemic hypertension. However, whether asymptomatic ventricular arrhythmias are specific markers for more severe sustained arrhythmias, or just markers for a more severe stage of the disease, remains to be determined.
在本综述中，将讨论6条证据，这些证据表明室性心律失常对系统性高血压和左心室肥厚患者具有预后意义：（1）在系统性高血压患者中，无症状性室性心律失常与左心室肥厚之间存在统计学关联；（2）在非高血压性左心室肥厚中，室性心律失常的预后价值是众所周知的；（3）左心室肥厚与系统性高血压患者的猝死有关；（4）人们普遍认为室性心律失常是猝死的常见原因；（5）有实验证据支持左心室肥厚的心律失常风险；（6）最近已证明室性心律失常会影响继发于系统性高血压的左心室肥厚患者的死亡率。然而，无症状性室性心律失常是更严重持续性心律失常的特异性标志物，还是仅仅是疾病更严重阶段的标志物，仍有待确定。
