Weinreich S, Hoebe B, Ivanyi P
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
Ann Rheum Dis. 1995 Sep;54(9):754-6. doi: 10.1136/ard.54.9.754.
To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE.
The relationship between maternal age at littering and frequency of AE was analysed.
Mice born to mothers aged eight months or older had a significantly lower disease frequency of AE than mice born to mothers younger than eight months of age. This phenomenon was observed in three independent cohorts evaluated to date (p < 0.01, 0.025, and 0.05).
Maternal age is a novel, non-genetic risk factor as defined in relation to an MHC associated enthesopathy. Its mode of action and relevance to human disease require further investigation.
在一项关于小鼠主要组织相容性复合体（MHC）H-2和转基因HLA-B27对强直性附着病（AE）发生率影响的研究中，对最初发现的强直性附着病的时间聚集性进行进一步研究。
分析产仔时母鼠年龄与AE发生率之间的关系。
8个月及以上母鼠所生的小鼠患AE的疾病发生率显著低于8个月以下母鼠所生的小鼠。在迄今评估的三个独立队列中均观察到了这一现象（p < 0.01、0.025和0.05）。
就与MHC相关的附着病而言，母鼠年龄是一个新的非遗传风险因素。其作用方式及与人类疾病的相关性有待进一步研究。
