母龄影响转基因小鼠中与HLA - B27相关的附着点病风险。
Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice.
作者信息
Weinreich S, Hoebe B, Ivanyi P
机构信息
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
出版信息
Ann Rheum Dis. 1995 Sep;54(9):754-6. doi: 10.1136/ard.54.9.754.
OBJECTIVE
To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE.
METHODS
The relationship between maternal age at littering and frequency of AE was analysed.
RESULTS
Mice born to mothers aged eight months or older had a significantly lower disease frequency of AE than mice born to mothers younger than eight months of age. This phenomenon was observed in three independent cohorts evaluated to date (p < 0.01, 0.025, and 0.05).
CONCLUSION
Maternal age is a novel, non-genetic risk factor as defined in relation to an MHC associated enthesopathy. Its mode of action and relevance to human disease require further investigation.
目的
在一项关于小鼠主要组织相容性复合体（MHC）H-2和转基因HLA-B27对强直性附着病（AE）发生率影响的研究中，对最初发现的强直性附着病的时间聚集性进行进一步研究。
方法
分析产仔时母鼠年龄与AE发生率之间的关系。
结果
8个月及以上母鼠所生的小鼠患AE的疾病发生率显著低于8个月以下母鼠所生的小鼠。在迄今评估的三个独立队列中均观察到了这一现象（p < 0.01、0.025和0.05）。
结论
就与MHC相关的附着病而言，母鼠年龄是一个新的非遗传风险因素。其作用方式及与人类疾病的相关性有待进一步研究。
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