Hasson T, Mooseker M S
Department of Biology, Yale University, New Haven, CT 06520, USA.
Curr Opin Cell Biol. 1995 Aug;7(4):587-94. doi: 10.1016/0955-0674(95)80017-4.
Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evidence has emerged that suggests roles for actin-based molecular motors in a wide range of membrane phenomena such as cell locomotion, phagocytosis, secretion, organelle transport, signal transduction and mechanoregulation of membrane protein function.
肌球蛋白是一大类结构多样的机械酶，与肌动蛋白丝相互作用时，可将ATP水解产生的能量转化为机械力。鉴于肌动蛋白与膜普遍存在关联，这些新型肌球蛋白中有许多都与膜相关。在过去两年中，有证据表明基于肌动蛋白的分子马达在多种膜现象中发挥作用，如细胞运动、吞噬作用、分泌、细胞器运输、信号转导以及膜蛋白功能的机械调节。
