Gould M N
University of Wisconsin-Madison, Department of Human Oncology 53792, USA.
Semin Cancer Biol. 1995 Jun;6(3):147-52. doi: 10.1006/scbi.1995.0023.
Rodent models have been, and continue to be, important in both defining the etiology of breast cancer, and in generating new prevention and treatment strategies directed at this prevalent malignancy. Of all solid cancers, breast cancer has the widest variety of rodent models. Models in rats and mice include both spontaneous, induced and transplantable carcinomas in standard strains. In addition, many strains are available for modeling inherited susceptibility and resistance to breast cancer. Finally, many new models that have taken advantage of techniques from biotechnology such as transgenic, knock-out and gene therapy technologies are being used to evaluate new prevention and treatment strategies for breast cancer.
啮齿动物模型过去一直并将继续在确定乳腺癌的病因以及制定针对这种常见恶性肿瘤的新预防和治疗策略方面发挥重要作用。在所有实体癌中，乳腺癌拥有种类最为繁多的啮齿动物模型。大鼠和小鼠模型包括标准品系中的自发性、诱发性和可移植性癌。此外，有许多品系可用于模拟遗传性易感性和对乳腺癌的抗性。最后，许多利用转基因、基因敲除和基因治疗技术等生物技术的新模型正被用于评估乳腺癌的新预防和治疗策略。
