Munn R J, Webster M, Muller W J, Cardiff R D
Department of Pathology, School of Medicine, University of California Davis 95616, USA.
Semin Cancer Biol. 1995 Jun;6(3):153-8. doi: 10.1006/scbi.1995.0020.
Mammary hyperplasias, dysplasias and tumors have been described in many strains of transgenic mice. Many of the transgenes produce characteristic disturbances of growth, development and neoplasia. The disturbances can now be classified into groups. A classification of transgenic tumors and an atlas illustrating some characteristic examples of common morphological changes in transgenic mammary tissues is provided.
在许多品系的转基因小鼠中都已发现乳腺增生、发育异常和肿瘤。许多转基因会导致生长、发育和肿瘤形成方面的特征性紊乱。现在这些紊乱可分为不同类别。本文提供了一份转基因肿瘤分类以及一本图谱，展示了转基因乳腺组织中一些常见形态学变化的典型例子。
