新型喹诺酮类药物左氧氟沙星（DR-3355）的体外抗分枝杆菌活性
In vitro antimycobacterial activity of a new quinolone, levofloxacin (DR-3355).
作者信息
Saito H, Sato K, Tomioka H, Dekio S
机构信息
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
出版信息
Tuber Lung Dis. 1995 Oct;76(5):377-80. doi: 10.1016/0962-8479(95)90001-2.
OBJECTIVE
To examine in vitro antimycobacterial activity of levofloxacin.
DESIGN
Minimum inhibitary concentrations (MICs) of levofloxacin for various mycobacterial species were determined by the agar dilution method using 7H11 medium and compared with those of ofloxacin. Antimicrobial activity of levofloxacin against Mycobacterium tuberculosis and M. intracellulare phagocytosed in murine peritoneal macrophages was measured in terms of reducing cell-associated bacterial colony forming units (CFUs).
RESULTS
MICs of levofloxacin against M. tuberculosis, M. kansasii, M. marinum, M. scrofulaceum, M. avium, M. intracellulare, M. fortuitum, and M. chelonae were 2 to 4 times lower than those of ofloxacin. Levofloxacin exhibited higher efficacy in reducing bacterial CFUs in macrophages than ofloxacin.
CONCLUSION
Levofloxacin possessed more potent in vitro antimycobacterial activities as compared to that of ofloxacin.
目的
检测左氧氟沙星的体外抗分枝杆菌活性。
设计
采用琼脂稀释法，使用7H11培养基测定左氧氟沙星对各种分枝杆菌的最低抑菌浓度（MICs），并与氧氟沙星的MICs进行比较。通过减少细胞相关细菌集落形成单位（CFUs）来测定左氧氟沙星对鼠腹膜巨噬细胞内吞噬的结核分枝杆菌和细胞内分枝杆菌的抗菌活性。
结果
左氧氟沙星对结核分枝杆菌、堪萨斯分枝杆菌、海分枝杆菌、瘰疬分枝杆菌、鸟分枝杆菌、细胞内分枝杆菌、偶然分枝杆菌和龟分枝杆菌的MICs比氧氟沙星低2至4倍。左氧氟沙星在降低巨噬细胞内细菌CFUs方面比氧氟沙星具有更高的效力。
结论
与氧氟沙星相比，左氧氟沙星具有更强的体外抗分枝杆菌活性。
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