Schimek F, Friess D, Fahle M
Department of Anesthesiology, Eberhard-Karls University, Tübingen, Germany.
Ger J Ophthalmol. 1995 Sep;4(5):315-9.
We compared plasma levels of lidocaine after the administration of proximal and peripheral blocks of the facial nerve in 30 cataract patients to evaluate the risk of systemic toxicity after both procedures. We performed the two block techniques with 5 ml 1% lidocaine solution plus (1:20,000) naphazoline nitrate as follows: the proximal block, at the dorsal rim of the mandible and the peripheral block, by subcutaneous infiltration of the lids. After the administration of the proximal block, mean plasma concentrations of lidocaine increased continuously for 15 min, whereas after the peripheral block they peaked within 12 min. Mean plasma concentrations were significantly lower following the proximal facial block than after the peripheral block of the facial nerve's terminal branches (P = 0.008-0.039, Wilcoxon test). In all patients, plasma concentration of lidocaine were below toxic levels.
我们比较了30例白内障患者在接受面神经近端阻滞和周围阻滞后面部利多卡因的血浆水平，以评估两种操作后全身毒性的风险。我们使用5毫升1%利多卡因溶液加（1:20,000）硝酸萘甲唑啉进行两种阻滞技术，具体如下：近端阻滞在下颌骨背侧边缘进行，周围阻滞通过眼睑皮下浸润进行。在进行近端阻滞后，利多卡因的平均血浆浓度持续升高15分钟，而在进行周围阻滞后，它们在12分钟内达到峰值。面神经近端阻滞术后的平均血浆浓度明显低于面神经终末支周围阻滞后的浓度（P = 0.008 - 0.039，Wilcoxon检验）。在所有患者中，利多卡因的血浆浓度均低于中毒水平。
