Thomsen L L, Iversen H K, Boesen F, Olesen J
Department of Neurology, Glostrup Hospital, University Hospital of Copenhagen, Denmark.
Brain. 1995 Oct;118 ( Pt 5):1319-27. doi: 10.1093/brain/118.5.1319.
The transcranial Doppler (TCD) and cardiovascular responses to established tests of autonomic function were studied in 50 migraineurs (23 of whom experienced aura and 27 who did not) and 30 healthy control subjects. In addition to the measurements outside attacks, 10 migraineurs were also tested during unilateral attacks of migraine without aura. Transcranial Doppler examinations of middle cerebral artery (MCA) blood velocity showed no differences between migraineurs and healthy subjects and no difference between migraineurs experiencing an attack and outside an attack when examined in response to a head-up tilt test, a cold-pressor test and a Valsalva manoeuvre. The cardiovascular reflexes in response to the Valsalva manoeuvre suggested a mild parasympathetic hypofunction in migraineurs, both those with and those without aura. On the basis of the present results and previous findings by others, we conclude that mild parasympathetic hypofunctioning with preserved sympathetic functioning is an established finding in migraine both with and without aura.
我们对50名偏头痛患者（其中23名有先兆，27名无先兆）和30名健康对照者进行了经颅多普勒（TCD）检查以及针对自主神经功能既定测试的心血管反应研究。除了在发作间期进行测量外，还对10名无先兆偏头痛患者的单侧发作期进行了测试。经颅多普勒对大脑中动脉（MCA）血流速度的检查显示，偏头痛患者与健康受试者之间无差异，并且在应对头高位倾斜试验、冷加压试验和瓦尔萨尔瓦动作时，有发作的偏头痛患者与发作间期的偏头痛患者之间也无差异。瓦尔萨尔瓦动作引发的心血管反射表明，有先兆和无先兆的偏头痛患者均存在轻度副交感神经功能减退。基于目前的研究结果以及其他人之前的发现，我们得出结论：无论是有先兆还是无先兆的偏头痛，均存在轻度副交感神经功能减退且交感神经功能保留这一既定现象。
