Pan M, Fischer C P, Wasa M, Lukaszewicz G, Stevens B R, Bode B P, Abcouwer S F, Souba W W
Shock. 1995 Aug;4(2):79-88. doi: 10.1097/00024382-199508000-00001.
Amino acid metabolism by the vascular endothelium is a complex process that often begins with the carrier-mediated uptake of circulating amino acids into the endothelial cytoplasm. Amino acids are essential for maintaining intact endothelial functions, which include cell proliferation, regulation of blood flow and vascular tone, coagulation and fibrinolysis, and metabolism of a variety of macromolecules. The disturbances in endothelial amino acid transport and metabolism that occur during infection and inflammation are due, in part, to changes in substrate availability and to the local and/or systemic elaboration of specific mediators. An improved understanding of endothelial amino acid metabolism will not only provide new knowledge regarding disease mechanisms and regulation, but may also lead to new treatment strategies that may include the clinical use of specific nutritional formulas.
血管内皮细胞的氨基酸代谢是一个复杂的过程，通常始于载体介导的循环氨基酸进入内皮细胞质的摄取过程。氨基酸对于维持完整的内皮功能至关重要，这些功能包括细胞增殖、血流和血管张力调节、凝血与纤维蛋白溶解以及多种大分子的代谢。感染和炎症期间发生的内皮氨基酸转运和代谢紊乱，部分归因于底物可用性的变化以及特定介质的局部和/或全身释放。更好地理解内皮氨基酸代谢不仅将提供有关疾病机制和调节的新知识，还可能导致新的治疗策略，其中可能包括特定营养配方的临床应用。
