Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Cells. 2022 Apr 18;11(8):1372. doi: 10.3390/cells11081372.
The vascular endothelium acts as an important component of the vascular system. It is a barrier between the blood and vessel wall. It plays an important role in regulating blood vessel tone, permeability, angiogenesis, and platelet functions. Several studies have shown that amino acids (AA) are key regulators in maintaining vascular homeostasis by modulating endothelial cell (EC) proliferation, migration, survival, and function. This review summarizes the metabolic and signaling pathways of AAs in ECs and discusses the importance of AA homeostasis in the functioning of ECs and vascular homeostasis. It also discusses the challenges in understanding the role of AA in the development of cardiovascular pathophysiology and possible directions for future research.
血管内皮作为血管系统的重要组成部分，是血液和血管壁之间的一道屏障。它在调节血管张力、通透性、血管生成和血小板功能方面发挥着重要作用。多项研究表明，氨基酸（AA）通过调节内皮细胞（EC）的增殖、迁移、存活和功能，是维持血管内稳态的关键调节剂。本综述总结了 AA 在 EC 中的代谢和信号通路，并讨论了 AA 内稳态在 EC 功能和血管内稳态中的重要性。还讨论了理解 AA 在心血管病理生理学发展中的作用所面临的挑战和可能的未来研究方向。
