三种市售检测水痘带状疱疹病毒抗体检测方法的比较。
Comparison of three commercially available assays for detection of varicella-zoster virus antibody.
作者信息
Martins T B, Jaskowski T D, Schroder C, Streeter B, Hill H R
机构信息
Department of Pathology, University of Utah School of Medicine, Salt Lake City 84108, USA.
出版信息
Clin Diagn Lab Immunol. 1994 Mar;1(2):186-8. doi: 10.1128/cdli.1.2.186-188.1994.
Three commercially available diagnostic assays for the detection of antibodies to varicella-zoster virus were evaluated to determine which would be the most suitable for our clinical laboratory. Three different methods were examined: an enzyme-linked immunosorbent assay (ELISA), latex agglutination (LA), and an indirect fluorescent-antibody technique. For the 141 serum specimens tested, the ELISA had an agreement of 90.1% and LA had an agreement of 92.2% with the indirect immunofluorescent-antibody technique. The ELISA had a lower sensitivity (85.6%) than LA (100.0%), but suffered from a low specificity (78.4%) compared with the ELISA (98.0%).
对三种市售的用于检测水痘-带状疱疹病毒抗体的诊断检测方法进行了评估，以确定哪一种最适合我们的临床实验室。研究了三种不同的方法：酶联免疫吸附测定（ELISA）、乳胶凝集试验（LA）和间接荧光抗体技术。对于所检测的141份血清标本，ELISA与间接免疫荧光抗体技术的一致性为90.1%，LA为92.2%。ELISA的敏感性（85.6%）低于LA（100.0%），但与LA（98.0%）相比，其特异性较低（78.4%）。
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