Torre D, Zeroli C, Pugliese A, Giola M, Ferrario G, Bonetta G, Issi M, Martegani R, Speranza F, Fiori G P
Division of Infectious Diseases, Regional Hospital, Varese, Italy.
Clin Diagn Lab Immunol. 1994 May;1(3):348-50. doi: 10.1128/cdli.1.3.348-350.1994.
We found a significant increase in fibronectin receptor (FNR) levels in the sera of adult human immunodeficiency virus type 1 (HIV-1)-infected patients, especially in those with AIDS (1,026.9 +/- 583.9 ng/ml; P < 0.0001). In contrast, AIDS patients with neurologic disorders and HIV-1-seropositive patients showed normal levels of FNR in serum. In addition, HIV-1-infected children showed increased levels of FNR in serum (824.4 +/- 333.5 ng/ml; P = 0.03). We suggest that an increase of FNR levels in AIDS patients is related to enhanced expression of FNR on HIV-1-infected cells.
我们发现,在成年1型人类免疫缺陷病毒(HIV-1)感染患者的血清中,纤连蛋白受体(FNR)水平显著升高,尤其是在艾滋病患者中(1,026.9±583.9 ng/ml;P<0.0001)。相比之下,患有神经疾病的艾滋病患者和HIV-1血清阳性患者的血清FNR水平正常。此外,HIV-1感染儿童的血清FNR水平升高(824.4±333.5 ng/ml;P = 0.03)。我们认为,艾滋病患者FNR水平的升高与HIV-1感染细胞上FNR表达增强有关。