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T cell fibronectin and mycobacterial adversarial strategy.T细胞纤连蛋白与分枝杆菌对抗策略。
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Interaction of human plasma fibronectin with viral proteins of human immunodeficiency virus.人血浆纤连蛋白与人类免疫缺陷病毒病毒蛋白的相互作用。
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Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.通过β1亚基激活α4β1整合素可诱导对纤连蛋白中RGDS序列的识别。
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Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection.1型人类免疫缺陷病毒感染的成人和儿童患者循环纤连蛋白受体水平
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In vitro binding of Candida albicans yeast cells to human fibronectin.白色念珠菌酵母细胞与人纤连蛋白的体外结合
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Fibronectin in parasitic diseases.寄生虫病中的纤连蛋白。
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor.鉴定并分离出一种140kd的细胞表面糖蛋白，其具有纤连蛋白受体所应有的特性。
Cell. 1985 Jan;40(1):191-8. doi: 10.1016/0092-8674(85)90322-8.
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Integrins: a family of cell surface receptors.整合素：一类细胞表面受体。
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Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.转化生长因子β可刺激培养的人肺成纤维细胞表达纤连蛋白以及人纤连蛋白受体的两个亚基。
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HIV-1感染患者T淋巴细胞上α5β1纤连蛋白受体的表达

Expression of the alpha 5 beta 1 fibronectin receptor on T lymphocytes of patients with HIV-1 infection.

作者信息

Torre D, Ferrario G, Issi M, Pugliese A, Speranza F

机构信息

Division of Infectious Diseases, Regional Hospital, Varese, Italy.

出版信息

J Clin Pathol. 1996 Sep;49(9):733-6. doi: 10.1136/jcp.49.9.733.

DOI:10.1136/jcp.49.9.733
PMID:9038757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500722/
Abstract

AIMS

To evaluate the expression of the alpha 5 beta 1 integrin fibronectin receptor (FNR), which mediates several processes, including phagocytosis, cell motility and the immune response, on T lymphocytes of patients with HIV-1 infection.

METHODS

T lymphocytes were incubated with monoclonal antibody directed against FNR and then with monoclonal antibodies, conjugated with phycoerythrin, directed against CD3, CD4 and CD8 positive cells. Expression of FNR on CD3, CD4 and CD8 positive cells was analysed using flow cytometry.

RESULTS

Normal expression of FNR was observed on CD3 positive cells from asymptomatic HIV positive patients and those with AIDS. Increased expression of FNR was observed on CD8 positive cells from asymptomatic HIV positive patients and on CD4 positive cells from patients with AIDS. Increased FNR expression was observed on CD4 positive cells from patients with AIDS, particularly those with opportunistic infections caused by Pneumocystis carinii, Mycobacterium sp, Toxoplasma gondii, and Cryptococcus neoformans.

CONCLUSION

Increased expression of FNR on CD8 and CD4 positive cells in asymptomatic HIV positive patients and those with AIDS, respectively, may be an epiphenomenon correlated with lymphocyte activation by HIV-1 or opportunistic infection, Further study is required to determine whether upregulation of FNR expression has a direct role in the pathogenesis of AIDS.

摘要

目的

评估α5β1整合素纤连蛋白受体（FNR）在HIV-1感染患者T淋巴细胞上的表达，该受体介导包括吞噬作用、细胞运动和免疫反应在内的多种过程。

方法

将T淋巴细胞与针对FNR的单克隆抗体孵育，然后与与藻红蛋白偶联的针对CD3、CD4和CD8阳性细胞的单克隆抗体孵育。使用流式细胞术分析FNR在CD3、CD4和CD8阳性细胞上的表达。

结果

在无症状HIV阳性患者和艾滋病患者的CD3阳性细胞上观察到FNR的正常表达。在无症状HIV阳性患者的CD8阳性细胞和艾滋病患者的CD4阳性细胞上观察到FNR表达增加。在艾滋病患者的CD4阳性细胞上观察到FNR表达增加，特别是那些由卡氏肺孢子虫、分枝杆菌属、弓形虫和新型隐球菌引起机会性感染的患者。

结论

无症状HIV阳性患者和艾滋病患者的CD8和CD4阳性细胞上FNR表达增加，可能是与HIV-1或机会性感染引起的淋巴细胞激活相关的一种附带现象。需要进一步研究以确定FNR表达上调在艾滋病发病机制中是否具有直接作用。