Bańkowski E
Rocz Akad Med Bialymst. 1994;39:1-6.
Liver fibrosis is accompanied by significant increase of collagen content in this organ. Chronic intoxication with ethanol is probably the most popular cause of liver fibrosis. Some experimental and clinical data suggest that acetaldehyde (an intermediary product of ethanol oxidation) is responsible for stimulation of collagen biosynthesis in the liver. It increases collagen gene transcription in fibroblasts. About 90% of exogenous ethanol is oxidized in liver providing an enhanced amount of acetaldehyde which triggers the fibrotic response.
肝纤维化伴随着肝脏中胶原蛋白含量的显著增加。乙醇慢性中毒可能是肝纤维化最常见的原因。一些实验和临床数据表明，乙醛（乙醇氧化的中间产物）是肝脏中胶原蛋白生物合成受刺激的原因。它增加了成纤维细胞中胶原蛋白基因的转录。约90%的外源性乙醇在肝脏中被氧化，产生大量乙醛，从而引发纤维化反应。
