Szynaka B, Andrzejewska A, Stokowska W
Department of Pathological Anatomy, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1994;39:121-9.
The purpose of this study was to evaluate the ultrastructural changes in the parotid gland of rats exposed to lead. The animals were given lead acetate in drinking water, at a concentration of 50 mg/dm3 Pb for periods of 2, 4 and 6 weeks. The ultrastructural examination showed that lead especially impaired mitochondria, caused accumulation of lipid droplets in the cytoplasm of acinar cells and inhibited the process of exocytosis of secretory granules. In the most extreme cases some acinar cells were destroyed.
本研究的目的是评估暴露于铅的大鼠腮腺的超微结构变化。给动物饮用含醋酸铅的水，浓度为50毫克/立方分米铅，持续2、4和6周。超微结构检查显示，铅尤其损害线粒体，导致腺泡细胞胞质内脂滴积累，并抑制分泌颗粒的胞吐过程。在最严重的情况下，一些腺泡细胞被破坏。
