Andrzejewska A, Szynaka B, Stokowska W
Department of Pathological Anatomy, Medical Academy, Białystok, Poland.
Mater Med Pol. 1994 Apr-Jun;26(2):65-8.
Clinical and experimental data point to the unfavorable effect of lead compounds on the oral cavity condition. The aim of this study was to analyse ultrastructural changes in the parotid gland of rats subjected to intoxication with lead acetate. The experiment was carried out on 24 Wistar rats divided into 4 groups, 6 animals in each. Group I animals were given aqueous solution of lead acetate of lead concentration 50 mg/dm3(50ppm), group II-500 mg/dm3(500ppm), group III-1,000 mg/dm3(1,000ppm). Control animals drank tap water. All the rats were sacrificed after six weeks of the experiment and material was collected for ultrastructural studies and evaluation of lead level in the tissue dry mass. A three fold increase in lead levels in the parotid gland was observed in group I and a tenfold increase in groups II and III. In all experimental ultrastructural examinations revealed groups in which lead impaired secretion of alveolar cells, damaged mitochondria and disturbed the lipid balance. The greatest destructive changes were observed in group III.
临床和实验数据表明铅化合物对口腔状况有不良影响。本研究的目的是分析用醋酸铅中毒的大鼠腮腺的超微结构变化。实验选用24只Wistar大鼠，分为4组，每组6只。第一组动物饮用铅浓度为50mg/dm³（50ppm）的醋酸铅水溶液，第二组为500mg/dm³（500ppm），第三组为1000mg/dm³（1000ppm）。对照组动物饮用自来水。实验六周后处死所有大鼠，收集材料用于超微结构研究和组织干重中铅含量的评估。第一组腮腺中铅含量增加了三倍，第二组和第三组增加了十倍。在所有实验中，超微结构检查显示铅损害了肺泡细胞的分泌、破坏了线粒体并扰乱了脂质平衡。第三组观察到的破坏性变化最大。
