Poteat H T, Corson J M, Fletcher J A
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Cancer Genet Cytogenet. 1995 Oct 1;84(1):76-81. doi: 10.1016/0165-4608(95)00090-9.
Fluorescence in situ hybridization (FISH) evaluations of chromosome 18 were performed in synovial sarcoma, hemangiopericytoma, and mesothelioma. Each case was evaluated with centromeric and whole chromosome paint probes. The synovial sarcomas had t(X;18) cytogenetically, but the FISH evaluator was blinded to the cytogenetic results and to the histopathologic diagnosis. The FISH analyses were consistent with chromosome 18 translocation in 6 of 7 synovial sarcomas, 0 of 3 hemangiopericytomas, and 0 of 1 mesothelioma. These findings support the use of FISH in the diagnosis of synovial sarcoma.
对滑膜肉瘤、血管外皮细胞瘤和间皮瘤进行了18号染色体的荧光原位杂交（FISH）评估。每个病例均使用着丝粒探针和全染色体涂染探针进行评估。滑膜肉瘤在细胞遗传学上具有t(X;18)，但FISH评估人员对细胞遗传学结果和组织病理学诊断不知情。FISH分析结果显示，7例滑膜肉瘤中有6例、3例血管外皮细胞瘤中有0例、1例间皮瘤中有0例存在18号染色体易位。这些发现支持将FISH用于滑膜肉瘤的诊断。
