Kamphuis J T, Huider M C, Ras G J, Verhagen C A, Kateman I, Vreeswijk J H, Burghouts J T
Department of Internal Medicine, Bosch Medicentrum, Location Grootziekengasthuis, NL's-Hertogenbosch, The Netherlands.
Cancer Chemother Pharmacol. 1995;37(1-2):190-2. doi: 10.1007/BF00685649.
A total of 14 patients with platinum-resistant advanced epithelial ovarian cancer were treated with a continuous infusion of high-dose 5-fluorouracil (5-FU, 1200 mg/m2 per day) for 2 consecutive days weekly for 4 weeks and, thereafter, every 2 weeks in combination with a push injection of folinic acid (20 mg/m2) given just before 5-FU and after 24 h. No objective response was documented, and only five patients showed stable disease. The median survival was 6.5 months. There was minimal toxicity. This schedule of 5-FU in combination with folinic acid is not effective as second-line chemotherapy in advanced ovarian cancer.
共有14例铂耐药晚期上皮性卵巢癌患者接受了连续输注高剂量5-氟尿嘧啶（5-FU，每天1200mg/m²）治疗，每周连续2天，共4周，此后每2周一次，并在5-FU给药前及给药后24小时推注亚叶酸（20mg/m²）。未记录到客观缓解，只有5例患者病情稳定。中位生存期为6.5个月。毒性极小。5-FU联合亚叶酸的这种方案作为晚期卵巢癌的二线化疗无效。
