Gross C R, Savik K, Bolman R M, Hertz M I
College of Pharmacy, School of Nursing, University of Minnesota, Minneapolis, USA.
Chest. 1995 Dec;108(6):1587-93. doi: 10.1378/chest.108.6.1587.
Health status and quality of life (QOL) in lung transplant candidates and recipients were compared to determine the impact of transplantation, and whether recipients experience continued improvements in the years after transplant surgery.
Two patient groups, adult lung transplant candidates (n = 44) and adult lung transplant recipients (n = 54), completed self-report QOL questionnaires. Eighteen of the 54 recipients completed QOL questionnaires on two occasions, about 18 months apart, after lung transplant. The questionnaire included the Medical Outcome Study Health Survey (MOS 20) that assesses six dimensions of health-related QOL: physical, role and social function, mental health, health perceptions and bodily pain, as well as a self-report Karnofsky Index and other indicators of QOL.
University medical center transplant service.
Compared with candidates, recipients reported higher levels of happiness and more satisfaction with their life and their health. They also reported better function on the Karnofsky Index and in every MOS 20 dimension (p < 0.0001), except pain. No significant differences were found in comparisons among recipients, grouped by the time since their transplant. Eighteen recipients completed two QOL questionnaires after transplant. No significant differences were found between the earlier (median, 11 months) and later (median, 29 months) QOL responses for this group overall. However, recipients (n = 5) who developed obliterative bronchiolitis between assessments showed decrements in their health-related QOL. Dimensions particularly affected were physical and social functioning and bodily pain.
Dramatic improvements in health status and QOL occur after successful lung transplant and remain stable over time. Obliterative bronchiolitis results in notable QOL reductions.
比较肺移植候选者和接受者的健康状况及生活质量（QOL），以确定移植的影响，以及接受者在移植手术后数年是否持续改善。
两个患者组，成年肺移植候选者（n = 44）和成年肺移植接受者（n = 54），完成了自我报告的生活质量问卷。54名接受者中的18名在肺移植后约18个月的两个时间点完成了生活质量问卷。问卷包括医学结果研究健康调查（MOS 20），该调查评估与健康相关的生活质量的六个维度：身体、角色和社会功能、心理健康、健康认知和身体疼痛，以及自我报告的卡诺夫斯基指数和其他生活质量指标。
大学医学中心移植服务部。
与候选者相比，接受者报告了更高水平的幸福感以及对生活和健康的更多满意度。他们在卡诺夫斯基指数和MOS 20的每个维度上也报告了更好的功能（p < 0.0001），疼痛维度除外。按移植后的时间分组，接受者之间的比较未发现显著差异。18名接受者在移植后完成了两份生活质量问卷。总体而言，该组早期（中位数为11个月）和晚期（中位数为29个月）的生活质量反应之间未发现显著差异。然而，在两次评估之间发生闭塞性细支气管炎的接受者（n = 5）显示其与健康相关的生活质量有所下降。受影响特别明显的维度是身体和社会功能以及身体疼痛。
成功的肺移植后健康状况和生活质量会显著改善，且随时间保持稳定。闭塞性细支气管炎会导致生活质量显著下降。
