Tsuchiya N, Harada Y, Taki M, Minematsu S, Maemura S, Amagaya S
Tsumura Central Laboratories, TSUMURA & Co., Ibaraki, Japan.
Exp Anim. 1995 Oct;43(5):671-8. doi: 10.1538/expanim1978.43.5_671.
Age-related changes of 27 items in serum chemistry were investigated in Sprague-Dawley rats of both sexes from 6 to 30 weeks of age. The following 12 items were shown as an increase in those values during growth and maturity, i.e., total protein, albumin (female only), glucose, total cholesterol, triglyceride, phospholipid (female only), beta-lipoprotein, cholinesterase (female only), asparate aminotransferase (female only), creatinine, direct-bilirubin and total-bilirubin. However, the following 4 items decreased with aging, i.e., asparate aminotransferase, alkaline phosphatase, creatine phosphokinase and inorganic phosphorus. No age-related changes were found in the values for calcium, sodium and chloride in both sexes and for alanine aminotransferase, cholinesterase and albumin in males. The sex differences were shown in the following 12 items: higher values in males were alkaline phosphatase, creatinephosphokinase, glucose and inorganic phosphorus, and higher values in females were cholinesterase, albumin, phospholipid, non-esterified fatty acid, urea nitrogen, direct-bilirubin, total-bilirubin and serum iron. No sex-related differences were found in the values for calcium, sodium, chloride and total cholesterol.
对6至30周龄的雌雄Sprague-Dawley大鼠血清化学中27项指标的年龄相关变化进行了研究。以下12项指标在生长和成熟过程中其值升高，即总蛋白、白蛋白（仅雌性）、葡萄糖、总胆固醇、甘油三酯、磷脂（仅雌性）、β-脂蛋白、胆碱酯酶（仅雌性）、天冬氨酸转氨酶（仅雌性）、肌酐、直接胆红素和总胆红素。然而，以下4项指标随年龄增长而降低，即天冬氨酸转氨酶、碱性磷酸酶、肌酸磷酸激酶和无机磷。在两性中钙、钠和氯以及雄性中丙氨酸转氨酶、胆碱酯酶和白蛋白的值未发现与年龄相关的变化。在以下12项指标中显示出性别差异：雄性中较高的值为碱性磷酸酶、肌酸磷酸激酶、葡萄糖和无机磷，而雌性中较高的值为胆碱酯酶、白蛋白、磷脂、非酯化脂肪酸、尿素氮、直接胆红素、总胆红素和血清铁。在钙、钠、氯和总胆固醇的值中未发现与性别相关的差异。
