Küpker W, al-Hasani S, Bauer O, Diedrich K, Schulze W
Universitätsfrauenklinik, Medizinischen Universität Lübeck.
Geburtshilfe Frauenheilkd. 1995 Sep;55(9):536-9. doi: 10.1055/s-2007-1022834.
Morphology of the spermatozoa is one of the major criteria in severe male subfertility. We report on a case of severe Oligoasthenoteratozoospermia in which a triplet pregnancy could be achieved after intracytoplasmic sperm injection (ICSI). After treatment with GnRH-analogues/HMG/HCG seven oocytes of metaphase II could be retrieved and injected. Three of them fertilised and were transferred as four-cell stage embryos after two days. Seven weeks later an intact triplet pregnancy could be detected by ultrasonography. The severe sperm defects in this case were evaluated with the technique of electron microscopy. Ultramorphology of spermatozoa appears to have an important predictive value for fertilisation and pregnancy in classical IVF. Its value for the assisted procreation techniques such as ICSI remains to be investigated.
精子形态是严重男性生育力低下的主要标准之一。我们报告一例严重少弱畸精子症病例，该患者经卵胞浆内单精子注射（ICSI）后成功实现三胎妊娠。经促性腺激素释放激素类似物/人绝经期促性腺激素/人绒毛膜促性腺激素治疗后，获取了7个处于减数分裂中期II的卵母细胞并进行注射。其中3个受精，两天后作为四细胞期胚胎进行移植。7周后，通过超声检查发现了完整的三胎妊娠。本病例中严重的精子缺陷通过电子显微镜技术进行评估。在经典体外受精中，精子的超微形态似乎对受精和妊娠具有重要的预测价值。其在诸如ICSI等辅助生殖技术中的价值仍有待研究。
