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Host and phi X 174 mutations affecting the morphogenesis or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate.宿主和噬菌体X 174的突变影响50S复合物的形态发生或稳定性，50S复合物是一种单链DNA合成中间体。
Genetics. 1995 Aug;140(4):1167-74. doi: 10.1093/genetics/140.4.1167.
2
The role of gene A protein and E. coli rep protein in the replication of phi X 174 replicative form DNA.基因A蛋白和大肠杆菌阻遏蛋白在φX 174复制型DNA复制中的作用。
Proc R Soc Lond B Biol Sci. 1980 Nov 19;210(1180):337-49. doi: 10.1098/rspb.1980.0138.
3
Rep protein as a helicase in an active, isolatable replication fork of duplex phi X174 DNA.Rep蛋白作为双链φX174 DNA活性、可分离复制叉中的解旋酶。
J Biol Chem. 1981 May 25;256(10):5294-8.
4
In vitro synthesis of bacteriophage phi X174 by purified components.利用纯化成分在体外合成噬菌体φX174 。
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Rolling-circle replication of UV-irradiated duplex DNA in the phi X174 replicative-form----single-strand replication system in vitro.在体外φX174复制型单链复制系统中紫外线照射的双链DNA的滚环复制
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phi X174 genome-capsid interactions influence the biophysical properties of the virion: evidence for a scaffolding-like function for the genome during the final stages of morphogenesis.噬菌体X174基因组与衣壳的相互作用影响病毒粒子的生物物理特性：形态发生最后阶段基因组具有类似支架功能的证据。
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The rolling circle . capsid complex as an intermediate in phi X DNA replication and viral assembly.滚环衣壳复合体作为噬菌体X DNA复制和病毒组装的中间体。
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Second-site suppressors of a cold-sensitive external scaffolding protein of bacteriophage phi X174.噬菌体φX174温度敏感型外部支架蛋白的第二位点抑制因子
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Analysis of the single-stranded DNA bacteriophage phi X174, refined at a resolution of 3.0 A.以3.0埃分辨率精制的单链DNA噬菌体φX174的分析。
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Characterization of the morphogenetic defects conferred by cold-sensitive prohead accessory and scaffolding proteins of phi X174.噬菌体φX174温度敏感型前头部辅助蛋白和支架蛋白所致形态发生缺陷的特征分析
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DNA packaging intermediates of bacteriophage φX174.噬菌体φX174的DNA包装中间体
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Formation of the parental replicative form DNA of bacteriophage phi-X174 and initial events in its replication.噬菌体φ-X174亲本复制型DNA的形成及其复制的起始事件。
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Nucleotide sequence and genome organization of bacteriophage S13 DNA.噬菌体S13 DNA的核苷酸序列与基因组结构
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Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly.小核糖核酸病毒衣壳的构象变异性：门戈病毒与宿主受体附着位点及解体相关的pH依赖性结构变化
Virology. 1990 Mar;175(1):176-90. doi: 10.1016/0042-6822(90)90198-z.
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Second-site suppressors of a cold-sensitive prohead accessory protein of bacteriophage phi X174.噬菌体φX174冷敏感前头部辅助蛋白的第二位点抑制子
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9
Functional relationship between the J proteins of bacteriophages phi X174 and G4 during phage morphogenesis.噬菌体φX174和G4的J蛋白在噬菌体形态发生过程中的功能关系。
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Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications.单链DNA噬菌体φX174的原子结构及其功能意义。
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宿主和噬菌体X 174的突变影响50S复合物的形态发生或稳定性，50S复合物是一种单链DNA合成中间体。

Host and phi X 174 mutations affecting the morphogenesis or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate.

作者信息

Ekechukwu M C, Oberste D J, Fane B A

机构信息

Department of Biological Sciences, University of Arkansas, Fayetteville 72701, USA.

出版信息

Genetics. 1995 Aug;140(4):1167-74. doi: 10.1093/genetics/140.4.1167.

DOI:10.1093/genetics/140.4.1167
PMID:7498760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1206684/
Abstract

The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate, which consists of a viral prohead and a DNA replicating intermediate (preinitiation complex). phi X 174 mutants, ogr (rep), which restore the ability to propagate in the mutant rep hosts, were isolated. The org (rep) mutations confer amino acid substitutions in the viral coat protein, a constituent of the prohead, and the viral A protein, a constituent of the preinitiation complex. Four of the six coat protein substitutions are localized on or near the twofold axis of symmetry in the atomic structure of the mature virion.

摘要

在特异性阻断III期单链DNA合成的rep突变宿主中研究了噬菌体phi X 174的形态发生途径。突变的rep蛋白造成的缺陷很可能影响50S复合物的形成或稳定性，50S复合物是一种单链DNA合成中间体，由病毒原头部和DNA复制中间体（预起始复合物）组成。分离出了phi X 174突变体ogr（rep），其恢复了在突变rep宿主中繁殖的能力。ogr（rep）突变导致病毒衣壳蛋白（原头部的一个组成部分）和病毒A蛋白（预起始复合物的一个组成部分）中的氨基酸替换。六个衣壳蛋白替换中有四个位于成熟病毒粒子原子结构中二重对称轴上或其附近。