Hofmann H
Allgemeines Krankenhaus der Stadt Wien, Abt. für Klinische Virologie, Austria.
Infection. 1995 May-Jun;23(3):133-8. doi: 10.1007/BF01793852.
Virus load was tested by means of PCR calibrated with standards and HCV genotypes were determined by the LIPA-technique using sera from 123 HCV patients. Of these 39 were on renal hemodialysis treatment, 19 suffered from hemophilia, 13 were i.v. drug users and the remaining 52 had none of these risk factors (chronic hepatitis group). The most prevalent subtype in Austria was 1b followed by 3a and 1a. However, genotype 1b infections were found relatively less often in hemophilia patients and drug users than in the other groups, indicating that hemophiliacs probably had been infected by an antihemophilic plasma coming from South American or Asian donors. The highest amounts of virus were found in patients infected with genotype 3a. Determination of the patient's virus load and of the infecting subtype of HCV may be helpful in planning interferon alpha therapy.
通过用标准品校准的聚合酶链反应（PCR）检测病毒载量，并采用LIPA技术，利用123例丙型肝炎病毒（HCV）患者的血清确定HCV基因型。其中39例接受肾脏血液透析治疗，19例患有血友病，13例为静脉注射吸毒者，其余52例无这些危险因素（慢性肝炎组）。奥地利最常见的亚型是1b，其次是3a和1a。然而，在血友病患者和吸毒者中发现1b基因型感染的频率相对低于其他组，这表明血友病患者可能是被来自南美或亚洲供血者的抗血友病血浆感染。在感染3a基因型的患者中发现病毒量最高。测定患者的病毒载量和HCV感染亚型可能有助于规划α干扰素治疗。
