Yoshihara T, Oda A, Takahashi Y, Ishii T, Yaku Y
Department of Otolaryngology, Tokyo Women's Medical College, Japan.
Int J Pediatr Otorhinolaryngol. 1995 Oct;33(2):171-8. doi: 10.1016/0165-5876(95)01206-q.
The case of an 8-month-old female with fibrous hamartoma of the tongue is reported with immunohistochemical and electron microscopic findings. An elastic hard mass at the base of the tongue gradually enlarged, causing dysphagia. The tumor was excised by CO2 laser. Under light microscopy, the tumor was observed as composed of fibroblast-like cells, fibrocollagenous bundles and striated muscle tissues. The majority of the cells were immunoreactive for vimentin. Electronmicroscopically, they contained numerous intermediate filaments, some had intercellular microvilli and cilia (9 + 2 type). These findings revealed that the cells of the fibrous hamartoma in our case may possess both mesenchymal and epithelial properties.
报告了一例8个月大患舌纤维性错构瘤的女性病例，并给出了免疫组化和电镜检查结果。舌根部一个质地硬如橡皮的肿块逐渐增大，导致吞咽困难。采用二氧化碳激光切除肿瘤。在光学显微镜下，观察到肿瘤由成纤维细胞样细胞、纤维胶原束和横纹肌组织构成。大多数细胞波形蛋白免疫反应呈阳性。在电镜下，这些细胞含有大量中间丝，有些还有细胞间微绒毛和纤毛（9 + 2型）。这些结果表明，我们病例中纤维性错构瘤的细胞可能兼具间充质和上皮特性。
