驻扎在加尔各答的中央后备警察部队流动人员中的发热病例。

Febrile episode among a floating population of C.R.P.F. Jawans stationed at Calcutta.

作者信息

Bhattacharjee N, De P M, Chakravarti S K, Chakraborty M S, Neogi D K, Mukherjee K K

机构信息

Department of Virology, School of Tropical Medicine, Calcutta, India.

出版信息

J Commun Dis. 1995 Jun;27(2):70-6.

PMID:7499775

Abstract

A virological investigation was carried out to establish the etiologic agent of a febrile outbreak amongst a floating population of C.R.P.F. Jawans, stationed at Calcutta during May-July, 1993. The illness was associated with fever, severe headache, bodyache and arthralgia which lasted for 2-4 days in most of the cases. Fifty cases were examined clinically and blood samples (both acute and convalescent) were subjected to virological study. One mouse-pathogenic agent could be isolated in suckling mice and identified as DEN-3. Sero-investigation of 50 single sera by HI & CF method revealed evidence of presumptive dengue infection in 33, while sero-conversion could be noted in 10 out of 25 available paired sera tested. Results of MAC ELISA revealed evidence of primary dengue infection in 6 out of 12 acute phase sera examined. Thus, the study shows that the episode is strongly suggestive of primary dengue infection.

摘要

开展了一项病毒学调查，以确定1993年5月至7月驻扎在加尔各答的中央后备警察部队（C.R.P.F.）流动人员中一次发热疫情的病原体。该疾病伴有发热、严重头痛、全身疼痛和关节痛，大多数病例持续2至4天。对50例病例进行了临床检查，并对血液样本（急性期和恢复期）进行了病毒学研究。在乳鼠中分离出一种小鼠致病因子，鉴定为登革3型。通过血凝抑制试验（HI）和补体结合试验（CF）对50份单份血清进行血清学调查，结果显示33份血清有推定登革热感染的证据，而在检测的25份可用双份血清中，有10份出现血清转化。微量细胞酶联免疫吸附试验（MAC ELISA）结果显示，在检测的12份急性期血清中，有6份有原发性登革热感染的证据。因此，该研究表明，此次疫情强烈提示为原发性登革热感染。