Gupta R C, Paul B S
Bull Environ Contam Toxicol. 1978 Dec;20(6):819-25. doi: 10.1007/BF01683606.
An oral dose of 0.5 mg/kg/day malathion continuously administered for one year has been investigated to produce no change in biochemical (RChE, PChE, aspartate- and alanine aminotransferases, blood glucose, serum urea and plasma total proteins) or haematological (Hb, PCV, tRBC and tWBC) parameters and, therefore, considered to be "no-effect-level" in Bubalus bubalis. However, the administration of higher doses (1.0 and 1.5 mg/kg/day) produced significant (P less than 0.05) changes in all biochemical parameters studied. With these doses leucocytosis was evident among haematological parameters measured.
已对水牛连续一年每天口服0.5毫克/千克马拉硫磷进行研究，结果表明其生化指标（红细胞胆碱酯酶、血浆胆碱酯酶、天冬氨酸转氨酶、丙氨酸转氨酶、血糖、血清尿素和血浆总蛋白）或血液学指标（血红蛋白、红细胞压积、总红细胞数和总白细胞数）均无变化，因此，该剂量被认为是水牛的“无效应水平”。然而，给予较高剂量（1.0和1.5毫克/千克/天）会使所有研究的生化指标发生显著（P小于0.05）变化。在这些剂量下，所测血液学指标中明显出现白细胞增多。
