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马拉硫磷（二乙基巯基琥珀酸的O，O'-二甲基二硫代磷酸酯）对水牛种皮肤亚急性毒性研究中机体酶的影响。

Influence of malathion (O,O'-dimethyl dithiophosphate of diethyl mercaptosuccinate) on body enzymes in dermal subacute toxicity studies in Bubalus bubalis species.

作者信息

Gupta R C, Paul B S

出版信息

Bull Environ Contam Toxicol. 1978 Dec;20(6):811-8. doi: 10.1007/BF01683605.

DOI:10.1007/BF01683605
PMID:219925
Abstract

The effect of daily dermal spray of malathion for four weeks in recommended (0.5 and 1.0 per cent) and higher (5.0 per cent) concentration on various enzymes in Bubalus bubalis species were studied. The higher concentration of 5.0 per cent showed lethal effect after 2 to 3 exposures. The cholinesterase activity in both RBC (RChE) and plasma (PChE) were inhibited with all the concentrations. There was also significant (P less than 0.05) elevation in the activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase with 1.0 and 5.0 per cent spray and enzyme activities remained altered even during post-medication. The extent of various biochemical changes were dose and time dependent.

摘要

研究了在推荐浓度（0.5%和1.0%）及更高浓度（5.0%）下，每日对水牛进行四周马拉硫磷皮肤喷雾，对其体内各种酶的影响。5.0%的较高浓度在2至3次暴露后显示出致死效应。所有浓度均抑制了红细胞（RChE）和血浆（PChE）中的胆碱酯酶活性。1.0%和5.0%喷雾处理后，血清天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶的活性也有显著（P小于0.05）升高，且在用药后酶活性仍保持改变。各种生化变化的程度与剂量和时间有关。

相似文献

1
Influence of malathion (O,O'-dimethyl dithiophosphate of diethyl mercaptosuccinate) on body enzymes in dermal subacute toxicity studies in Bubalus bubalis species.马拉硫磷（二乙基巯基琥珀酸的O，O'-二甲基二硫代磷酸酯）对水牛种皮肤亚急性毒性研究中机体酶的影响。
Bull Environ Contam Toxicol. 1978 Dec;20(6):811-8. doi: 10.1007/BF01683605.
2
"No-effect-level" of malathion (o,o'-dimethyl dithiophosphate of diethyl mervaptosuccinate) in Bubalus bubalis.水牛体内马拉硫磷（二乙基巯基琥珀酸酯的o,o'-二甲基二硫代磷酸酯）的“无作用水平”
Bull Environ Contam Toxicol. 1978 Dec;20(6):819-25. doi: 10.1007/BF01683606.
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Acute malathion toxicosis and related enzymatic alterations in Bubalus bubalis: antidotal treatment with atropine, 2-PAM, and diazepam.水牛急性马拉硫磷中毒及相关酶变化：阿托品、解磷定和地西泮的解毒治疗
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In vitro study on the comparative inhibitory effect of malathion, sumithion & hinosan on blood cholinesterase of Bubalus bubalis.马拉硫磷、杀螟硫磷及氯己定对水牛血液胆碱酯酶抑制作用的体外比较研究
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Arch Environ Contam Toxicol. 1977;6(1):23-31. doi: 10.1007/BF02097746.

本文引用的文献

1
A comparative pharmacological and toxicological study of organic phosphate-anticholinesterase compounds.有机磷酸酯类抗胆碱酯酶化合物的比较药理学和毒理学研究
J Pharmacol Exp Ther. 1952 Jun;105(2):156-65.
2
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.一种测定血清谷草转氨酶和谷丙转氨酶的比色法。
Am J Clin Pathol. 1957 Jul;28(1):56-63. doi: 10.1093/ajcp/28.1.56.
3
The toxicity of organic phosphorus insecticides to livestock.有机磷杀虫剂对家畜的毒性。
J Am Vet Med Assoc. 1957 Mar 1;130(5):215-6.
4
Acute coumaphos toxicosis in cattle: antidotal therapy with pralidoxime chloride and atropine, and related alterations of blood and serum enzymatic activities.牛急性蝇毒磷中毒：用氯解磷定和阿托品进行解毒治疗以及血液和血清酶活性的相关变化
Am J Vet Res. 1971 Jul;32(7):1053-63.
5
Effect of protein malnutrition on cholesterol and phosphatases in the lungs of silicotic rats.蛋白质营养不良对矽肺大鼠肺中胆固醇和磷酸酶的影响。
Int Arch Arbeitsmed. 1972;29(2):119-23. doi: 10.1007/BF00539870.
6
Response of adaptive rat liver enzymes to acute poisoning by organophosphate insecticides.适应性大鼠肝脏酶对有机磷杀虫剂急性中毒的反应。
Toxicol Appl Pharmacol. 1966 Mar;8(2):266-76. doi: 10.1016/s0041-008x(66)80013-3.
7
The intracellular release of lysosomal contents in macrophages that have ingested silica.已吞噬二氧化硅的巨噬细胞中溶酶体内容物的细胞内释放。
J Histochem Cytochem. 1970 May;18(5):368-71. doi: 10.1177/18.5.368.
8
The biochemical effects of coumaphos and three oximes on certain enzyme systems and blood protein elements in cattle.蝇毒磷和三种肟对牛某些酶系统及血液蛋白质成分的生化作用。
Am J Vet Res. 1966 Jan;27(116):177-85.