两性霉素B持续膀胱冲洗与间歇性膀胱冲洗治疗念珠菌尿症的比较
Continuous versus intermittent bladder irrigation of amphotericin B for the treatment of candiduria.
作者信息
Trinh T, Simonian J, Vigil S, Chin D, Bidair M
机构信息
Department of Urology, San Diego Veterans Affairs Medical Center, California, USA.
出版信息
J Urol. 1995 Dec;154(6):2032-4.
PURPOSE
The efficacy of continuous versus intermittent bladder irrigation with amphotericin B in the treatment of candiduria was compared.
MATERIALS AND METHODS
A prospective, randomized and comparative pilot study was done on 20 patients. Continuous bladder irrigation with 50 mg./l. amphotericin B infused during 24 hours for 2 days was compared to 3 intermittent bladder irrigations of 10 mg./100 ml. amphotericin B in 1 day. Urine cultures were obtained 72 hours after treatment.
RESULTS
The organism was eradicated in 8 patients (80%) who received continuous irrigation and 3 (30%) who received intermittent irrigation (p = 0.035).
CONCLUSIONS
Continuous amphotericin B bladder irrigation was superior in terms of efficacy, ease of administration and patient comfort.
目的
比较两性霉素B持续膀胱冲洗与间断膀胱冲洗治疗念珠菌尿症的疗效。
材料与方法
对20例患者进行了一项前瞻性、随机对照试验性研究。将24小时内持续输注50mg/L两性霉素B并持续2天的膀胱冲洗与1天内3次间断膀胱冲洗10mg/100ml两性霉素B进行比较。治疗72小时后进行尿培养。
结果
接受持续冲洗的8例患者（80%）病原体被清除，接受间断冲洗的3例患者（30%）病原体被清除（p = 0.035）。
结论
两性霉素B持续膀胱冲洗在疗效、给药便利性和患者舒适度方面更具优势。
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