Chikaraishi T, Ishikura H, Seki T, Koyanagi T, Yoshiki T
Department of Urology, Hokkaido University School of Medicine, Sapporo, Japan.
J Urol. 1995 Dec;154(6):2197-202.
The effect of short-term administration of 15-deoxyspergualin (DSG), 5 mg./kg./day from postoperative days 4 to 7, on rat renal transplantation was studied.
Although allografts treated with DSG survived longer than nontreated ones, cellular infiltration in both grafts did not differ. However, renal tubular cells of DSG-treated grafts proliferated well and escaped apoptotic cell death. A donor-specific tolerance 2 weeks after transplantation was developed, and cells with in vitro suppressor function were induced in such animals.
Treatment with DSG appears to prevent lethal attack of effector cells on tubular cells in situ and to generate suppressor cells in the maintenance phase of graft enhancement.
研究术后第4天至第7天每天给予15 - 去氧精胍菌素（DSG）5毫克/千克对大鼠肾移植的影响。
虽然用DSG处理的同种异体移植物存活时间比未处理的长，但两种移植物中的细胞浸润没有差异。然而，用DSG处理的移植物的肾小管细胞增殖良好，未发生凋亡性细胞死亡。移植后2周形成了供体特异性耐受，并且在这类动物中诱导出具有体外抑制功能的细胞。
DSG治疗似乎可防止效应细胞对原位肾小管细胞的致命攻击，并在移植物增强的维持阶段产生抑制细胞。
