Perez R M, Perez S, Zavala M A, Salazar M
Escuela Superior de Ingenieria Quimica e Industrias extractivas, I.P.N., México D.F., Mexico.
J Ethnopharmacol. 1995 Jul 7;47(2):85-90. doi: 10.1016/0378-8741(95)01257-e.
The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a protective effect on heat-induced erythrocyte lysis at concentrations of 25, 50 and 100 micrograms/ml. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB). It may be inferred that the ethanol extract is effective against both exudative-proliferative and chronic phases of inflammation.
使用多种动物模型对植物翅叶海桑的乙醇提取物的抗炎作用进行了研究。在25 - 100毫克/千克的剂量下，它对角叉菜胶诱导的爪肿胀产生了显著抑制作用，并减轻了棉球诱导的肉芽肿的重量。在浓度为25、50和100微克/毫升时，发现该提取物对热诱导的红细胞溶血具有保护作用。在甲醛和佐剂性关节炎的慢性模型中，发现其抗关节炎活性低于保泰松（PNB）。可以推断，乙醇提取物对炎症的渗出-增殖期和慢性期均有效。
