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双嘧达莫治疗大鼠心肌毛细血管壁细胞的增殖活性

Proliferative activity of myocardial capillary wall cells in dipyridamole--treated rats.

作者信息

Tornling G, Unge G, Skoog L, Ljungqvist A, Carlsson S, Adolfsson J

出版信息

Cardiovasc Res. 1978 Nov;12(11):692-5. doi: 10.1093/cvr/12.11.692.

DOI:10.1093/cvr/12.11.692
PMID:750082
Abstract

The hearts of rats treated with dipyridamole were studied by light microscope autoradiography and measurement of tissue radioactivity after intravenous injection of 3H-thymidine. Total tissue radioactivity was significantly increased in the hearts of the dipyridamole-treated animals. Only capillary wall cells were labelled in the autoradiograms. The observations indicate a proliferation of capillary wall cells, suggesting a neoformation of myocardial capillaries during dipyridamole treatment.

摘要

在用双嘧达莫治疗的大鼠心脏中,通过光学显微镜放射自显影术以及静脉注射3H-胸腺嘧啶核苷后测量组织放射性来进行研究。双嘧达莫治疗组动物心脏的总组织放射性显著增加。放射自显影片中仅毛细血管壁细胞被标记。这些观察结果表明毛细血管壁细胞增殖,提示在双嘧达莫治疗期间心肌毛细血管有新生。

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1
Proliferative activity of myocardial capillary wall cells in dipyridamole--treated rats.双嘧达莫治疗大鼠心肌毛细血管壁细胞的增殖活性
Cardiovasc Res. 1978 Nov;12(11):692-5. doi: 10.1093/cvr/12.11.692.
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Proliferative activity of capillary wall cells in skeletal muscle of rats during long-term treatment with dipyridamole.
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The proliferative activity of myocardial capillary wall cells in variously aged swimming-exercised rats.
Acta Pathol Microbiol Scand A. 1979 Jan;87(1):15-7. doi: 10.1111/j.1699-0463.1979.tb00018.x.
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Dipyridamole-induced neoformation of capillaries in the rat heart. Quantitative stereological study on papillary muscles.双嘧达莫诱导大鼠心脏毛细血管新生。乳头肌的定量体视学研究。
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Dipyridamole and capillary proliferation. A preliminary report.
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Time dependence of dipyridamole-induced increase in skeletal muscle capillarization.双嘧达莫诱导骨骼肌毛细血管化增加的时间依赖性。
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Dipyridamole-induced capillary endothelial cell proliferation in the rat heart--a morphometric investigation.双嘧达莫诱导大鼠心脏毛细血管内皮细胞增殖——一项形态计量学研究。
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Capillary proliferative activity in myocardium and skeletal muscle of exercised rats.运动大鼠心肌和骨骼肌中的毛细血管增殖活性。
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