长期使用丁螺环酮对大鼠海马不同区域的5-HT1A和5-HT2A受体mRNA及结合位点有不同的调节作用。

Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus.

作者信息

Chen H, Zhang L, Rubinow D R, Chuang D M

机构信息

Section on Molecular Neurobiology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.

出版信息

Brain Res Mol Brain Res. 1995 Sep;32(2):348-53. doi: 10.1016/0169-328x(95)00098-d.

DOI:10.1016/0169-328x(95)00098-d

PMID:7500848

Abstract

Groups of rats were treated with buspirone (1 mg/kg/day) for 21 days using osmotic minipumps implanted subcutaneously. After buspirone treatment, the 5-HT1A receptor mRNA levels were significantly decreased in the CA1 and CA2 of the hippocampus, but were markedly increased in the dentate gyrus (DG), CA3 and CA4. The level of the 5-HT1A receptor binding sites was not significantly changed in these subhippocampal areas. Buspirone treatment markedly increased 5-HT2A receptor mRNA levels in the DG, CA2, CA3 and CA4. This was accompanied by a significant increase in the level of 5-HT2A receptor binding sites in all subhippocampal regions. These results demonstrate that chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA as well as their expressed binding sites in various regions of the hippocampus.

摘要

使用皮下植入的渗透微型泵，将大鼠分组用丁螺环酮（1毫克/千克/天）处理21天。丁螺环酮处理后，海马体CA1和CA2区5-HT1A受体mRNA水平显著降低，但在齿状回（DG）、CA3和CA4区显著升高。这些海马下区域的5-HT1A受体结合位点水平没有显著变化。丁螺环酮处理显著增加了DG、CA2、CA3和CA4区的5-HT2A受体mRNA水平。这伴随着所有海马下区域5-HT2A受体结合位点水平的显著增加。这些结果表明，慢性丁螺环酮处理可差异性地调节海马不同区域的5-HT1A和5-HT2A受体mRNA及其表达的结合位点。