Camici M, Sagripanti A, Barsotti G, Baicchi U, Evangelisti L, Morelli E, Giovannetti S
Istituto di Clinica Medica II, Ospedale S. Chiara, Università degli Studi, Pisa.
Minerva Med. 1995 Sep;86(9):353-5.
Activated partial thromboplastin time (aPTT) during heparin infusion in 10 patients on regular dialytic treatment was evaluated. At end-dialysis (3 hours) plasma heparinization ranged between 2000-4000 IU and from the clinical point of view dialytic performance was good. At end-dialysis aPTT was 53 +/- 14 seconds: this value is under the prescribed aPTT prolongation (1.5-2 times baseline values) to achieve a therapeutic heparin plasma level. Physiopathological implications of this aPTT "resistance" to heparin infusion are studied.
对10例接受常规透析治疗的患者在肝素输注期间的活化部分凝血活酶时间（aPTT）进行了评估。在透析结束时（3小时），血浆肝素化范围在2000 - 4000 IU之间，从临床角度看透析性能良好。透析结束时aPTT为53±14秒：该值低于规定的aPTT延长（基线值的1.5 - 2倍）以达到治疗性肝素血浆水平。研究了这种aPTT对肝素输注“抵抗”的生理病理学意义。
