Murphy G M, Bitting L, Majewska A, Schmidt K, Song Y, Wood C R
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5485, USA.
Neurosci Lett. 1995 Aug 25;196(3):153-6. doi: 10.1016/0304-3940(95)11862-q.
Interleukin-11 (IL-11) is a pleiotropic cytokine with important effects on hematopoietic and other cells. IL-11 was originally described as a product of stromal cell lines and fibroblasts. Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore. The neuroblastoma cell line SH-SY5Y did not express IL-11 mRNA in response to these agents. Cerebral expression of IL-11 by glial cells is important because IL-11 has been shown to have effects on neuronal electrophysiology, has overlapping functions with the neuroactive cytokine interleukin-6, and is part of the gp130-associated neuropoietic family of cytokines.
