Herrmann J J, Eramo L R
Department of Pediatrics, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA.
Pediatr Dermatol. 1995 Sep;12(3):248-51. doi: 10.1111/j.1525-1470.1995.tb00170.x.
Congenital apocrine hamartomas are rare tumors of the skin composed of mature apocrine glands in the papillary and reticular dermis. Several cases have been reported in the literature but few were of uniform clinical appearance. The term apocrine nevus has been used interchangeably with apocrine hamartoma in the literature, however, based on their distinctive morphologies we believe they are different entities. We describe a 7-year-old girl with a congenital apocrine hamartoma of the left cheek. A stained biopsy specimen from the lesion revealed large mature apocrine glands with decapitation secretion in the dermis. The presence of periodic acid-Schiff-positive, diastase-resistant granular material in the apical cytoplasm of some secretory cells helped differentiate these as apocrine glands. We think this lesion may represent a form of organoid nevus with pure apocrine differentiation.
先天性大汗腺错构瘤是一种罕见的皮肤肿瘤，由乳头层和网状真皮层中的成熟大汗腺组成。文献中已有数例报道，但临床表现一致的病例较少。文献中大汗腺痣这一术语与大汗腺错构瘤可互换使用，然而，基于它们独特的形态，我们认为它们是不同的实体。我们描述了一名患有左侧脸颊先天性大汗腺错构瘤的7岁女孩。病变部位的染色活检标本显示真皮层有大量成熟的大汗腺，伴有断头分泌。一些分泌细胞顶端细胞质中存在高碘酸-希夫阳性、抗淀粉酶颗粒物质，有助于将这些细胞鉴别为大汗腺。我们认为这种病变可能代表一种具有纯大汗腺分化的类器官痣。
