Faucher J F, Baltz T, Petry K G
INSERM U394, Bordeaux, France.
Parasitol Res. 1995;81(5):441-3. doi: 10.1007/BF00931508.
Monoclonal antibody (mAb) DION 5.1b, derived from mice immunized with Trypanosoma dionisii, recognizes a 72/76-kD surface glycoprotein specific to the epimastigote stage of T. dionisii and T. cruzi. None of the three other stages of the T. cruzi life cycle expresses any DION 5.1b-specific epitope. However, mAb DION 5.1b labels an intracellular form with "epimastigote-like" morphology that appears to be late and transient in the intracellular cycle. This result suggests that the morphological similarity between the observed "epimastigote-like" intracellular form in mammals and the epimastigote form in insects may extent to the antigenic pattern.
单克隆抗体（mAb）DION 5.1b由用杜氏锥虫免疫的小鼠产生，可识别杜氏锥虫和克氏锥虫前鞭毛体阶段特有的一种72/76-kD表面糖蛋白。克氏锥虫生命周期的其他三个阶段均不表达任何DION 5.1b特异性表位。然而，mAb DION 5.1b标记了一种具有“类前鞭毛体”形态的细胞内形式，该形式在细胞内周期中似乎出现较晚且是短暂的。这一结果表明，在哺乳动物中观察到的“类前鞭毛体”细胞内形式与昆虫中的前鞭毛体形式之间的形态相似性可能延伸至抗原模式。
