Pazzaglia P J, Post R M, Rubinow D, Kling M A, Huggins T S, Sunderland T
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1390, USA.
Psychiatry Res. 1995 Aug 28;57(3):259-66. doi: 10.1016/0165-1781(95)02704-z.
Cerebrospinal fluid (CSF) total protein was evaluated in 240 patients with affective disorders and compared with findings in 55 normal comparison subjects. Subtype diagnoses were as follows: bipolar I (n = 108, 47 men, 61 women); bipolar type II (n = 67, 26 men, 41 women); and unipolar (n = 65, 22 men, 43 women). Men had significantly elevated values compared with women. In men with bipolar I disorder, mean CSF protein levels were found to be significantly elevated over those in normal subjects, with 31.9% above the traditional normal range cutoff of 45 mg/dl. Moreover, CSF protein levels in male bipolar I patients were found to be positively correlated with severity of depression at the time of the lumbar puncture and with duration of illness. It thus appears that increased protein levels may be associated with illness severity or progression in male patients with bipolar I disorder. Although elevated CSF protein is a nonspecific marker of cerebral pathology, further search for the potential underlying pathophysiological mechanisms related to this finding would now appear to be warranted.
对240例情感障碍患者的脑脊液（CSF）总蛋白进行了评估，并与55名正常对照者的结果进行了比较。亚型诊断如下：双相I型（n = 108，男47例，女61例）；双相II型（n = 67，男26例，女41例）；单相（n = 65，男22例，女43例）。男性的值显著高于女性。在双相I型障碍男性患者中，发现脑脊液蛋白平均水平显著高于正常受试者，31.9%超过了45mg/dl的传统正常范围临界值。此外，发现男性双相I型患者的脑脊液蛋白水平与腰椎穿刺时的抑郁严重程度以及病程呈正相关。因此，似乎蛋白水平升高可能与双相I型障碍男性患者的疾病严重程度或进展有关。虽然脑脊液蛋白升高是脑部病理的非特异性标志物，但现在似乎有必要进一步寻找与这一发现相关的潜在病理生理机制。
