Sobis H, Waer M, Vandeputte M
Rega Institute for Medical Research, University of Leuven, Belgium.
Tumour Biol. 1996;17(1):13-9. doi: 10.1159/000217962.
A possible relationship between the development of granulated metrial gland (GMG) cells and trophoblast was studied. Trophoblast implanted in ectopic sites (e.g. kidney capsule) did not induce decidua and did not recruit GMG cells. Only when injected in utero did trophoblast lead to the development of decidua and to the recruitment of GMG cells. With malignant trophoblast (choriocarcinoma cells) similar results were obtained as with normal trophoblast both after ectopic or after in utero injection. The presence of decidua, but not the development of a conceptus or the outgrowth of trophoblast, seems to be required for the differentiation of GMG cells.
研究了颗粒状子宫内膜腺（GMG）细胞发育与滋养层之间的可能关系。植入异位部位（如肾被膜）的滋养层不会诱导蜕膜形成，也不会募集GMG细胞。只有当在子宫内注射时，滋养层才会导致蜕膜发育并募集GMG细胞。对于恶性滋养层（绒毛膜癌细胞），在异位注射或子宫内注射后，得到了与正常滋养层相似的结果。GMG细胞的分化似乎需要蜕膜的存在，而不是孕体的发育或滋养层的生长。
