Peel S, Stewart I
Faculty of Medicine, University of Southampton, U.K.
Cell Differ Dev. 1989 Oct;28(1):55-64. doi: 10.1016/0922-3371(89)90023-3.
Shielding an ovary and part of the uterus of mice during irradiation allowed chimeric mice, reconstituted with rat or mouse bone marrow (respectively, RBM and MBM chimeras), to be studied in a subsequent pregnancy. Some of the granulated metrial gland (GMG) cells which differentiated in the RBM chimeric mice were rat GMG cells, showing the contribution of donor bone marrow precursors to the uterine response to pregnancy. Rat and mouse GMG cells were found in the maternal blood spaces of the placental labyrinth adjacent to the degenerate layer 1 trophoblast. This suggests that both rat and mouse GMG cells exhibit cytotoxic activity against the mouse trophoblast.
在对小鼠进行辐射时对其卵巢和部分子宫进行屏蔽，使得用大鼠或小鼠骨髓重建的嵌合小鼠（分别为RBM嵌合体和MBM嵌合体）能够在后续妊娠中进行研究。在RBM嵌合小鼠中分化的一些颗粒化子宫蜕膜腺（GMG）细胞是大鼠GMG细胞，这表明供体骨髓前体细胞对子宫妊娠反应有贡献。在与退化的1层滋养层相邻的胎盘迷路的母体血腔中发现了大鼠和小鼠GMG细胞。这表明大鼠和小鼠GMG细胞均对小鼠滋养层表现出细胞毒性活性。
