高胃泌素血症的后果。
The consequences of hypergastrinemia.
作者信息
Creutzfeldt W
机构信息
Department of Medicine, Georg-August-University, Göttingen, Germany.
出版信息
Yale J Biol Med. 1994 May-Aug;67(3-4):181-94.
The only gastrin-dependent gastric endocrine cells are the fundic ECL cells. Excessive hypergastrinemia stimulates ECL cell proliferation in animals and man. The growth of other gastric endocrine cells is regulated by the gastric pH. Hypergastrinemia in man results in diffuse and linear hyperplasia of the ECL cells, while micronodular hyperplasia is correlated to the grade of corpus gastritis. ECL cell dysplasia and gastric carcinoids in man have been observed only in patients with gastrinoma as part of the MEN I syndrome and with pernicious anemia. Gastrin dependence of GI adenocarcinoma has not been established. Experimental findings may be explained by the presence of gastrin receptors and the role of gastrin as an autocrine growth factor. Epidemiological data do not support gastrin dependence of carcinoma of the stomach, the pancreas and the colon.
仅胃底肠嗜铬样（ECL）细胞是依赖胃泌素的胃内分泌细胞。胃泌素过多血症会刺激动物和人类的ECL细胞增殖。其他胃内分泌细胞的生长受胃内pH值调节。人类高胃泌素血症会导致ECL细胞弥漫性和线性增生，而微结节性增生与胃体胃炎的程度相关。仅在患有胃泌素瘤（作为多发性内分泌腺瘤病I型综合征的一部分）和恶性贫血的患者中观察到人类ECL细胞发育异常和胃类癌。胃肠道腺癌对胃泌素的依赖性尚未确立。实验结果可能是由于胃泌素受体的存在以及胃泌素作为自分泌生长因子的作用。流行病学数据不支持胃癌、胰腺癌和结肠癌对胃泌素的依赖性。
Zotero 插件