Susini C, Esteve J P, Bommelaer G, Vaysse N, Ribet A
Digestion. 1978;18(5-6):384-93. doi: 10.1159/000198224.
The effect of somatostatin on the pancreatic exocrine response to different doses of exogenous stimuli and the somatostatin dose-response relationships on pancreatic secretion were studied in conscious dogs. Somatostatin caused a strong inhibition of basal or slightly stimulated pancreatic secretion but failed to inhibit the maximal responses, suggesting that somatostatin interacts with secretin or caerulein by a competitive mechanism. A higher maximal percentage of inhibition and a dose-response relationship was observed with protein outputs and enzyme concentrations. Volumes and bicarbonate outputs were also inhibited but the maximal percentage of inhibition was lower.
在清醒犬中研究了生长抑素对胰腺对外源性不同剂量刺激的外分泌反应的影响以及生长抑素对胰腺分泌的剂量-反应关系。生长抑素强烈抑制基础或轻度刺激的胰腺分泌，但不能抑制最大反应，提示生长抑素通过竞争机制与促胰液素或雨蛙肽相互作用。在蛋白质输出量和酶浓度方面观察到更高的最大抑制百分比和剂量-反应关系。体积和碳酸氢盐输出量也受到抑制，但最大抑制百分比更低。
