Miyata Y, Tsuda H, Matayoshi-Miyasato K, Fukushima S, Murasaki G, Ogiso T, Ito N
Gan. 1978 Dec;69(6):845-8.
The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100 IU/g diet (P less than 0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.
在雄性Wistar大鼠中测定了乙酸维生素A对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）膀胱致癌性的影响。在不给予致癌物的情况下给予乙酸维生素A，所给药剂量未引起膀胱或其他器官的变化。然而，维生素A过多症抑制了BBN诱导的膀胱病变中的角质化和鳞状化生，且当饮食中剂量大于100 IU/g时，膀胱移行细胞癌和乳头状瘤的发生率显著降低（P<0.02）。本实验表明，对于大鼠膀胱上皮，维生素A过多症降低了对BBN致瘤性的易感性。
