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在乳糜泻病变中，TCRγ/δ⁺和CD8⁺TCRα/β⁺上皮内淋巴细胞（IEL）表达增殖标志物（Ki-67）。

TCR gamma/delta + and CD8+TCR alpha/beta + intraepithelial lymphocytes (IEL) express proliferation marker (Ki-67) in the coeliac lesion.

作者信息

Halstensen T S, Brandtzaeg P

机构信息

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), National Hospital, University of Oslo, Norway.

出版信息

Adv Exp Med Biol. 1995;371B:1333-8.

DOI:
PMID:7502812
Abstract

In conclusion, it appears that gluten induces a non-proliferative activation of CD4+ lamina propria T cells, but a proliferative activation in the TCR alpha/beta +CD8+ and TCR gamma/delta + IEL subsets. Although the increased density of TCR alpha/beta +CD8+ and TCR gamma/delta + IEL in the coeliac lesion may be secondary to T cell mediated immune activation in the lamina propria, a direct and primary antigen-driven proliferation of IEL (perhaps CD1-dependent29) cannot be excluded.

摘要

总之，麸质似乎可诱导固有层CD4+ T细胞发生非增殖性激活，但在TCRα/β +CD8+和TCRγ/δ + IEL亚群中则诱导增殖性激活。尽管乳糜泻病变中TCRα/β +CD8+和TCRγ/δ + IEL密度增加可能继发于固有层中T细胞介导的免疫激活，但不能排除IEL（可能是CD1依赖性的）直接由抗原驱动的原发性增殖。

相似文献

[1]
TCR gamma/delta + and CD8+TCR alpha/beta + intraepithelial lymphocytes (IEL) express proliferation marker (Ki-67) in the coeliac lesion.

Adv Exp Med Biol. 1995

[2]
Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium.

Eur J Immunol. 1993-2

[3]
Phenotypical and functional characterization of small intestinal TcR gamma delta + T cells in coeliac disease.

Scand J Immunol. 1992-4

[4]
Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet.

Gut. 1993-2

[5]
Intraepithelial TcR alpha/beta+ lymphocytes express CD45RO more often than the TcR gamma/delta+ counterparts in coeliac disease.

Immunology. 1990-12

[6]
Targeting of gliadin peptides, CD8, alpha/beta-TCR, and gamma/delta-TCR to Golgi complexes and vacuoles within celiac disease enterocytes.

FASEB J. 1998-10

[7]
Progenies of fetal thymocytes are the major source of CD4-CD8+ alpha alpha intestinal intraepithelial lymphocytes early in ontogeny.

Eur J Immunol. 1994-8

[8]
In situ two- and three-color immunofluorescence staining of mucosal T-cells in celiac disease. Increase of TCR gamma/delta+CD8- and TCR alpha/beta+CD45R0+ intraepithelial lymphocytes and IL-2R+ TCR alpha/beta+CD4+CD45R0+ lamina propria lymphocytes.

Prog Histochem Cytochem. 1992

[9]
Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

J Immunol. 1991-12-1

[10]
Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease.

Scand J Immunol. 1989-12

引用本文的文献

[1]
A gluten-free diet lowers NKG2D and ligand expression in BALB/c and non-obese diabetic (NOD) mice.

Clin Exp Immunol. 2014-8

[2]
Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease.

PLoS One. 2013-10-4

[3]
Intraepithelial lymphocytes in celiac disease immunopathology.

Semin Immunopathol. 2012-6-3

[4]
The surface epithelium of recurrent infected palatine tonsils is rich in gammadelta T cells.

Clin Exp Immunol. 1998-1

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