文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

在乳糜泻中，上皮内T细胞受体α/β⁺淋巴细胞比T细胞受体γ/δ⁺淋巴细胞更常表达CD45RO。

Intraepithelial TcR alpha/beta+ lymphocytes express CD45RO more often than the TcR gamma/delta+ counterparts in coeliac disease.

作者信息

Halstensen T S, Farstad I N, Scott H, Fausa O, Brandtzaeg P

机构信息

Institute of Pathology, University of Oslo, National Hospital, Norway.

出版信息

Immunology. 1990 Dec;71(4):460-6.

DOI:
PMID:2149120
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384863/
Abstract

Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly more often (75%) than the preferentially expanded TcR gamma/delta+ counterpart (59%). Triple staining for CD3, CD4/8 and CD45RA or CD45RB revealed that all CD3 + 4 - 8 - IEL (taken to be TcR gamma/delta+) expressed CD45RB and none were CD45RA. CD45RO positivity was of the same magnitude (66%) on the predominating monoclonal antibody delta TCS1-reactive fraction of TcR gamma/delta+ cells as on the remainder of the TcR gamma/delta+ subset. These results suggest that gluten exposition in patients with coeliac disease leads to accumulation of CD45RA-, putative antigen-primed memory cells of both TcR phenotypes. The less marked CD45RO expression within the preferentially expanded TcR gamma/delta+ subset of IEL may be of particular biological interest.

摘要

通过对21例乳糜泻患者和8名对照者空肠组织切片进行三色免疫荧光原位研究，分析了携带α/β或γ/δ T细胞受体（TcR）的上皮内淋巴细胞（IEL）上CD45RO的表达情况。CD45RA-TcRα/β+ IEL表达CD45RO的比例（75%）显著高于优先扩增的TcRγ/δ+对应细胞（59%）。对CD3、CD4/8和CD45RA或CD45RB进行三重染色显示，所有CD3 + 4 - 8 - IEL（被认为是TcRγ/δ+）均表达CD45RB，且无CD45RA表达。在TcRγ/δ+细胞中占主导的单克隆抗体δTCS1反应性部分，CD45RO阳性率（66%）与TcRγ/δ+亚群的其余部分相同。这些结果表明，乳糜泻患者接触麸质会导致两种TcR表型的CD45RA-、假定的抗原致敏记忆细胞积累。IEL中优先扩增的TcRγ/δ+亚群内CD45RO表达较弱，可能具有特殊的生物学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/45fc044ce0bd/immunology00127-0008-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/0432f73f662e/immunology00127-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/c2e3862f248d/immunology00127-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/9392bc7120be/immunology00127-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/5277c0561b0f/immunology00127-0008-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/45fc044ce0bd/immunology00127-0008-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/0432f73f662e/immunology00127-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/c2e3862f248d/immunology00127-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/9392bc7120be/immunology00127-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/5277c0561b0f/immunology00127-0008-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a9/1384863/45fc044ce0bd/immunology00127-0008-c.jpg

相似文献

[1]
Intraepithelial TcR alpha/beta+ lymphocytes express CD45RO more often than the TcR gamma/delta+ counterparts in coeliac disease.

Immunology. 1990-12

[2]
Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium.

Eur J Immunol. 1993-2

[3]
Phenotypical characterization of peripheral blood T cells in patients with coeliac disease: elevation of antigen-primed CD45RO+ T lymphocytes.

Immunology. 1995-9

[4]
Phenotypic changes and proliferative activity of human gamma delta T cell receptor-bearing cells upon activation.

Clin Exp Immunol. 1991-6

[5]
Human CD8+ intraepithelial T lymphocytes are mainly CD45RA-RB+ and show increased co-expression of CD45R0 in celiac disease.

Eur J Immunol. 1990-8

[6]
Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood.

Eur J Immunol. 1990-5

[7]
Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease.

Scand J Immunol. 1989-12

[8]
Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease.

Clin Exp Immunol. 1991-6

[9]
Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.

J Immunol. 1996-9-1

[10]
Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: predominance of T cell receptor alpha/beta+/CD2- cells and high expression of the RT6 alloantigen.

Eur J Immunol. 1991-3

引用本文的文献

[1]
T Cell Response Toward Tissue-and Epidermal-Transglutaminases in Coeliac Disease Patients Developing Dermatitis Herpetiformis.

Front Immunol. 2021

[2]
Anti-TCR gamma antibody in celiac disease: the value of count on formalin-fixed paraffin-embedded biopsies.

Virchows Arch. 2013-7-17

[3]
The adaptive immune response in celiac disease.

Semin Immunopathol. 2012-4-26

[4]
Age-related variation of intraepithelial lymphocytes subsets in normal human duodenal mucosa.

Dig Dis Sci. 2007-3

[5]
Feeding NOD mice with pig splenocytes induces transferable mechanisms that modulate cellular and humoral xenogeneic reactions against pig spleen or islet cells.

Clin Exp Immunol. 2002-3

[6]
Circulating T lymphocyte subsets in coeliac disease (CoD) patients and healthy family members.

Clin Exp Immunol. 1998-3

[7]
Immunopathology of gluten-sensitive enteropathy.

Springer Semin Immunopathol. 1997

[8]
The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance.

Immunology. 1996-11

[9]
Effect of chronic graft-versus-host disease on the intestine in adult BDF1 mice.

Int J Exp Pathol. 1993-8

[10]
Distribution of dominant T cell receptor beta chains in human intestinal mucosa.

J Exp Med. 1994-10-1

本文引用的文献

[1]
Identification of a putative second T-cell receptor.

Nature. 1986

[2]
The isolation and characterization of the human helper inducer T cell subset.

J Immunol. 1985-6

[3]
The isolation and characterization of the human suppressor inducer T cell subset.

J Immunol. 1985-3

[4]
Restricted production of interleukin 4 by activated human T cells.

Proc Natl Acad Sci U S A. 1988-12

[5]
T-cell antigen receptor genes and T-cell recognition.

Nature. 1988-8-4

[6]
Characterization of CD45 and CD45R monoclonal antibodies using transfected mouse cell lines that express individual human leukocyte common antigens.

J Immunol. 1988-12-1

[7]
Expression of the gamma-delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes.

Nature. 1988-6-30

[8]
Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

J Exp Med. 1988-4-1

[9]
Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

J Immunol. 1988-4-1

[10]
The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.

J Exp Med. 1989-3-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索